Evaluating the bioactive compounds content, toxicological aspects and antibacterial/antifungal activities of the reishi mushroom (Ganoderma lucidum) ethanol extract

نوع المستند : المقالة الأصلية

المؤلفون

1 جامعه بورسعيد كلية التربية النوعية

2 قسم الاقتصاد المنزلي - کلية التربية النوعية جامعة بورسعيد - بور سعيد - مصر

3 کلية الاقتصاد المنزلى - جامعة المنوفية

4 جامعه بورسعيد كليه تربيه نوعيه اقتصاد منزلي

المستخلص

 Reishi mushroom (Ganoderma lucidum, family Ganodermaceae) is spread
worldwide and is widely used for several nutritional and medical purposes. Therefore,
knowledge of all aspects of this mushroom's composition, toxicity and biological activities is
required. The present study aims to determine the bioactive compound content, toxicity
studies, and antibacterial/antifungal activities of Ganoderma lucidum ethanol extract (GLEE). Data on the nutrients composition of Ganoderma lucidum powder indicated that crude
fiber and carbohydrates were the largest compounds (51.06 ± 2.42 and 36.17 ± 3.91%,
respectively), followed by total protein (8.69 ± 0.69 %), ash (2.21 ± 0.14%) and crude fat
(1.87 ± 0.20%.). Also, Furthermore, the nutraceuticals (bioactive compounds) content of GLEE indicated that terpenoids were the largest compound (241.47± 20.72 mg linalol.100 g-1)
followed by polysaccharides (154.30± 19.06 mg starch equivalent.100 g-1), phenolics (49.98 ±
5.61 mg gallic acid equivalent.100g-1), triterpenoids (51.16 ± 6.49 mg ursolic acid.100 g-1).
Furthermore, GL-EE recorded antibacterial and antifungal. On the other side, the toxicity
studies of GL-EE were evaluated in Albino rats using standard methods. Various doses (2000
and 5000 mg/kg) of the extract were orally administered to rats and kept under close
observation for the next 10 days. Data from the acute toxicity study did not show any toxicity
signs and symptoms at doses 2000 mg/kg and 5000 mg/kg of GL-EE. Such signs and
symptoms, including no morbidity or mortality, were observed. As a result, the LD50 of the
Gl-EE could be greater than 5000mg/kg body weight. The effective biotransformation and
elimination of this natural product within a short period. Therefore, the present study
recommended that Ganoderma lucidum extract (GL-EE) could be used safely in different
nutritional and medical applications.

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