The Protective Effect of White Tea and Lemon Grass Against Nephrotoxicity in Rats

نوع المستند : المقالة الأصلية

المؤلفون

1 Department of Nutrition, Faculty of Home Economics, Helwan University.

2 Department of Home Economics, Faculty of Specific Education, Port Said University.

المستخلص

The study aimed to evaluate the protective effect of white tea and lemon grass powder with their antioxidant effect against carbon tetrachloride (CCl4) induced kidney toxicity in rats. Forty-eight albino rats were separated into 8 groups (6 of each), the first group fed the basal diet only and served as a negative control, and groups 2-to and 8 intraperitonially injected with CCl4 to cause kidney toxicity twice a week through the experimental period (28 days). Group 2 received the basal diet and served as a positive control, groups 3 and 4 received the basal diet with 2.5 and 5% WTP, groups 5 and 6 received the basal diet with 2.5 and 5% LGP and groups 7 and 8 received the basal diet with 2.5 and 5% WTP and LGP mixture. At the end of the trial period, blood samples from each rat after overnight fasting were collected to biochemical assays. Results revealed that both study materials contained a percentage of polyphenols with high levels of DPPH, especially in lemon grass. Moreover, lactate dehydrogenase, blood urea nitrogen, creatinine, total cholesterol, triglycerides, very low-density lipoprotein-cholesterol, and low-density lipoprotein-cholesterol were significantly decreased while, high-density lipoprotein-cholesterol was significantly increased. Furthermore, catalase was significantly increased whereas malondialdehyde was decreased. Therefore, this study suggests the possibility of using both white tea powder and lemon grass in preventing kidney toxicity factors in humans after conducting further studies on them.

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