POSSIBLE EFFECTS OF MILK THISTLE SEEDS EXTRACT ON OBESITY AND ITS RELATED OXIDATIVE STRESS AND NEUROLOGICAL COMPLICATIONS IN DIET-INDUCED OBESITY MODEL IN RAT

نوع المستند : المقالة الأصلية

المؤلفون

1 قسم التغذية وعلوم الاطعمة - کلية الاقتصاد المنزلى - جامعة المنوفية

2 قسم الاقتصاد المنزلي - کلية التربية النوعية جامعة بورسعيد

3 قسم الاقتصاد المنزلى، کلية التربية النوعية، جامعة بورسعيد

4 قسم الاقتصاد المنزلي - كلية التربية النوعية - جامعة بورسعيد

المستخلص

The present study investigated the potential effects of Milk thistle (Silybum marianum L.) seeds extract (SMSE) on obesity and its related oxidative stress and neurological complications in diet-induced obesity model in rat. Thirty-six rats were divided into two main groups: Group 1 (6 rats) received a basic diet (BD), while other main group (30 rats) was used for obesity induction by feed on diet induced obesity (DIO) for 8 weeks and classified into five sub groups as follow: group (2), model control, fed on basal diet (BD) only as a positive control (rats with obesity) and groups (3-6) fed on BD and administered by oral gavages, using a feeding needle with 150, 300, 450, and 600 mg/kg bw/day SMSE, respectively. At the end of the 8-week period, the obese control group saw increases of 27.97%, 15.36%, and 16.00% for body weight (BW) gain weight, food intake (FI) and the feed efficiency ratio (FER), respectively compared to the normal animals group. Treatment with SMSE (150, 300, 450 and 600 mg/100 mg/kg bw/day) in feeding rats for 8 weeks led to a significant (p≤0.05) reduction in BW, FI, and FER among obese rats. Furthermore, SMSE effectively improved obesity-related conditions by protecting the liver by reducing serum enzyme activity, increasing antioxidant levels (GSH and GSSG), decreasing biological oxidants levels (reactive oxygen species, ROS and malondialdehyde, MDA) and improving neurological markers (acetylcholine esterase, dopamine and serotonin). In conclusion, date of the present study suggested that dietary modifications with SMSE can help mitigate obesity-related complications,

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